Claimed in Camacho's paper it is the major factor, besides electrostatic forces, that governs or helps protein binding, elevating the k-on constant by several orders of magnitude.
Inspired on their implementation I should realise the desolvation forcefield in this way
a) find the surface patches that are less than 4.2A in distance;
b) add the area of the surface to a total value;
c) proportionate this value to energy;
d) find the unit vector of this virtual desolvation force;
e) calculate the force.
Before doing this, a robust reading-from/writing-to-file routine should be written to automate the surface meshing to save computing time/power.
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